The 27-year-old singer recently split from Selena after 10 months of dating, and he has now decided to remove any trace of his ex-girlfriend from his page on the photo-sharing website.
The Canadian star previously had a number of sweet snaps of Selena on his page, including one dating back to April this year in which she is seen clutching his face and giving him a kiss on the cheek.
By contrast, Selena - who recently rekindled her romance with Justin Bieber - still has a series of pictures featuring her ex on her own Instagram page.
Among the pictures still appearing on Selena's Instagram is one of her first red carpet appearance alongside The Weeknd at the Met Gala in May.
The Weeknd's decision to remove Selena from his Instagram account came shortly after it was reported that her family are ''still getting comfortable'' with the idea of her reuniting with Justin.
Selena and the 'Sorry' musician recently decided to give their relationship another try, having ended their five-year on/off romance in 2015.
But while the high-profile duo seem happier than ever together, Selena's family are said to be less than thrilled with the idea.
Speaking after the Thanksgiving holiday, an insider explained: ''They both spent Thanksgiving with their families. Justin went to Canada and Selena was in Texas. They are still doing really well together, but they agreed it was best for them to be with their families for the holiday.
''Selena felt it was too soon for Justin to come to Texas with her. Her family is still getting comfortable with the idea of them back together.''