The Lorenzo's Oil co-stars had been tapped to play the heads of America's former First Family in TV series Graves, but Sarandon has since exited the project due to "artistic differences", according to producers at U.S. cable network Epix.

A replacement is expected to be announced in the near future.

The show is set to feature Nolte as an ex-president who attempts to right his administration's wrongs as his wife seeks to fulfil her own political ambitions.

Graves is due to premiere next summer (16), in the run-up to the real-life race for the White House.