Royal Blood, who opened the show at the O2 Academy Brixton with a performance, picked up Best New Band and Best Live Band, while Jamie T claimed the night's Best Video and Best Track honours for Zombie, before walking off with the Music Moment of the Year for his 'comeback'.
Kasabian were also double winners, landing the Best British Band award and Best Album prize for 48:13.
Boom Clap singer Charlie Xcx, who also sang at the event, picked up the Dancefloor Filler prize for her Fancy collaboration with Iggy Azalea, and Dave Grohl's Foo Fighters were named Best International Band.
The rockers used the event to announce they would be headlining this summer's (15) Glastonbury festival in England, shortly after last year's (14) event was named Best Festival.
The absent band sent in a video, during which Grohl said, "This is amazing, we love you very much, but we also love all of the fans for voting for our band for this award. We're very thankful and very happy.
"Sorry we couldn't make it tonight, but we will be seeing you over the summer at some big outdoor festival that nobody knows we're playing. It's Glastonbury! So we'll see you at Glastonbury."
Other winners included Jake Bugg (Solo Artist), Dean Blunt (Philip Hall Radar Award for Best Up-and-Coming Artist), and Suede, who scored the 2015 Godlike Genius career achievement award.
The main list of prize winners at the 2015 NME Awards is:
Dancefloor Filler - Charlie Xcx
Best Festival - Glastonbury
Phillip Hall Radar Award - Dean Blunt
Best Video - Zombie by Jamie T
Solo Artist - Jake Bugg
Best International Band - Foo Fighters
Best Music Film - Pulp: A Film About Life, Death & Supermarkets
Best Film - Northern Soul
Best Track - Zombie by Jamie T
Best New Band - Royal Blood
Best Reissue - The Holy Bible by Manic Street Preachers
Music Moment of the Year - Jamie T's comeback
Best Album - 48:13 by Kasabian
Best Live Band - Royal Blood
Best British Band - Kasabian
Rock'n'Roll Soul Award - Jimmy Page
Godlike Genius Award - Suede.