Patrick Dempsey's wife has reportedly filed for divorce after 15-years of marriage.

Jillian Fink, who married the 'Grey's Anatomy' star in July 1999, has cited irreconcilable differences as the reason for their split and is seeking joint custody of their 12-year-old daughter, Tallulah Fyfe, and seven-year-old twin sons, Sullivan Patrick and Darby Galen.

The make-up artist, 48, is also requesting spousal and child support, and a source told gossip website ''She's all about the kids.''

The 49-year-old actor has an estimated $40 million fortune and the former couple do not have a prenuptial agreement.

The insider added: ''It remains to be seen whether it will be amicable.''

Patrick, who was married to Rocky Parker from 1987 to 1994, previously credited Jillian for helping him to stay grounded.

He said: ''The best part about being married is feeling centered. Nothing else matters so much as long as you can come home and be with your family.''

But he also admitted they were both very independent people.

He said: ''She'll do things on her own so she can come back and be much more patient with the kids. I go car racing.''