The music extravaganza will return to Discovery Park in Sacramento, California from October 6th to 9th 2022, and the British rockers will step in for the 'Monkey Wrench' hitmakers - who were due to headline on October 9th - after they pulled out following the death of their drummer Taylor Hawkins in March aged 50.
Muse frontman Matt Bellamy said in a statement: "It's been too long and we can't wait to come back to Northern California and headline Aftershock on Sunday, October 9th in Sacramento."
In February, it was announced Foo Fighters, Slipknot, Kiss, Rob Zombie and My Chemical Romance would all be headliners at this year's Aftershock festival, which will be bigger than ever after expanding from three-and-a-half days to four full days.
Rob said: "Aftershock is one of our favourite festivals.
"Always an amazing weekend. We are ready to take it to the next level this year."
Jacoby Shaddix, Papa Roach's frontman, admitted it is a "dream come true" for the 'Broken Home' hitmakers to be headlining the festival.
He said: "I am over the moon stoked to be one of the headliners of Aftershock this year.
"Honestly, this is like a dream come true. We have worked our whole career for moments like this, and cannot wait to be back in Sacramento, where it all began, for the hometown throwdown!
"NorCal better be f****** ready, cause it's about to go down at Aftershock 2022!"
Several other acts will also perform over the four days, including Bring Me the Horizon, Evanescence, Lamb of God, and Stone Temple Pilots.
Evanescence frontwoman Amy Lee admitted the group "cannot wait" to perform.
She said: "We are so stoked to play at Aftershock in Sacramento this fall!"
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