The Material Girl hitmaker appeared as the hip-hop star performed a track named after the pop icon and she then added a medley of her own hits, including Human Nature and Express Yourself.

At one point during her set, she walked up behind Drake, pulled his head back and locked lips with him.

Madonna then strutted off stage and Drake yelled out, "Oh s**t, what the f**k just happened?"

The singer has since shared pictures and videos of the smooch on Twitter.com.