The 38-year-old singer is now raising his 13-year-old nephew, Til, after his brother-in-law passed away in November at the age of 46. Til's mother also died in 2007.
Country music star Luke Bryan and his wife Caroline Bryan, whom he married in December 2006, are parents to two sons, Thomas, 6, and Tatum, 4, but now the 38-year-old singer is also raising another little boy.
Bryan is now taking care of his 13-year-old nephew
Bryan recently opened up to ABC News about the death of his brother-in-law, Ben Lee Cheshire, who passed away in November at the age of 46, and how his 13-year-old nephew Til is now living with the rest of his family in Nashville.
"We feel like if we just stay positive through this, maybe we'll be a positive inspiration for people that had these things happen to 'em," Bryan said. "You just have to plow on and play the hand that's dealt."
What is even more heart-breaking is that Bryan's sister, who is Til's mother, also unexpectedly died seven years ago, aged 39.
"It's every day on the phone all day trying to talk with the family and figure out what to do, but it's what you gotta do," he said. "Tough stuff."
Although he admitted their situation can become overwhelming at times, Bryan realises that all of his family, including his two older sisters, will look towards him for strength.
"You know, we just stay positive. I think people expect that from me," he continued. "I have to pray that people that have had similar situations can maybe look at my family and see me positively dealing with it. I'm not saying it's easy."
The 'Country Man' singer also spoke openly about is family tragedies while he was being honoured at the American Country Countdown Awards in December.
"I want to thank all of my fans for the last couple of weeks in my life, for keeping my family in your prayers," he said while being presented with the Male Vocalist of the Year award. "And I wanna also recognize the country music community, all the artists. Fans, let me explain something to you: you guys support wonderful artists, because they have rallied around me and helped me and my family through the last couple of weeks. It's just nice to feel loved in a situation."