The rock legend will be taking the two-day event to New York's fabled Madison Square Garden and he has compiled a stellar line-up for the benefit shows, which raise funds for his Crossroads rehabilitation facility in Antigua.
B.B. King, the Allman Brothers Band, Citizen Cope, Gary Clark Jr., Keith Urban and Los Lobos have also signed up for the big gigs on 12 and 13 April (13).
It will be Clapton's fourth Crossroads festival since its launch in Dallas, Texas in 2004. Two other shows have also been staged in Illinois in 2007 and 2010.
Clapton had previously suggested the 2010 bash would be the last, but he subsequently had a change of heart and agreed to keep the festival going.