Ellen, Patrick, Sandrah Oh, Justin Chambers, James Pickens Jr. and Chandra Wilson have reportedly put pen to paper on new two-year deals that will see the ABC medical drama continue through the 2013/14 season, taking the programme past a 10th series, according to TVLine.
'Grey's Anatomy' - which is currently in its eighth season - attracted 9.25 million viewers in the US last week, and the show looks set to become one of the longest-running medical dramas in TV history.
Earlier this year, Katherine Heigl admitted she wants to return to the show, despite leaving in a storm of controversy in 2010 after criticising her character Dr. Izzie Stevens.
She previously said: ''I've told them I want to [return]. I don't know ... Being a showrunner and being a writer of a TV series like that is so complicated that I mean she's got how many characters are there now? There's a lot and so she's balancing about 40 different storylines, so I don't know if it fits in to their sort of vision for this season or next or however many seasons it goes.''
Series narrator and lead female star Ellen - who has played Meredith Grey since the show started in 2005 - insisted she would be happy to continue portraying the surgical resident.
She explained: ''If I hear from the fans that they want us to keep going, then I would continue because we owe them everything.''