Knight, who oversaw Cube and Dre's careers after they left the rap group, was visiting the set when an altercation broke out between him and a group of other men. In his haste to leave the scene, the fallen record label boss struck and killed one man and injured another.
He is currently behind bars fighting for his freedom amid charges of hit-and-run and murder.
Dr. Dre tells The Hollywood Reporter he was on the set when Knight arrived, but had left when the scuffle broke out.
He explains, "I was just leaving, so I didn't know what happened until I was halfway home.
"I heard about it over the phone. Everybody was supportive everywhere we went, and we didn't have one issue throughout the entire filming of the movie. It's crazy that this happened during the f**king filming of the commercial. It's just a really unfortunate incident."
And Ice Cube, who wasn't on the set, admits he's upset the drama is overshadowing the film's upcoming release: "Some people don't care if you're making a movie or not. It's unfortunate because the movie is so good, so creative, so many talented people involved."
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