The 'Bangarang' hitmaker - whose real name is Sonny John Moore - claims the musician helped him pursue his dream of being a famous artist, but criticised him for his ''negative attitude''.
In an interview on New York radio station AMP 92.3, he explained: ''I'll always have love for Joel because he put me on at an early time, but he's an a**hole. And everyone knows that, and he knows that. And that's kinda his thing.
''The one thing that is unfortunate about it is he has a record label and when you have a record label you've got to be a leader and he has people that are signed to him. I couldn't imagine being a leader, going out [with] a public image being such a negative attitude.''
However, Deadmau5 - whose real name is Joel Thomas Zimmerman - hit back with a series of tweets in which he acknowledged he can be a ''f***ing diva'' but insisted Skrillex should ''let [him] worry about that s**t''.
The 34-year-old DJ raged: ''thanks for that pocket full of certified psychoanalysis. its really unfortunate i have a label. sorry for being me.
''at the end of the f***ing day, if im ''miserable / moody / negative'' then thats just me dealing with or not dealing internal s**t.
''yes. im aware that i can be a f***ing diva. yes i am aware than i have more than one complex. very f***ing aware.
''the people you should REALLY f***ing worry about, are the people who dont know it.
''so YES @skrillex im SUPER SAD im not as cheerful, and super inspired by life like you. and im so SORRY im an a**hole. but how about...
''you let me worry about that s**t. (sic)''
The young artist urges fans to vote like their lives depend on it.
Billie Eilish is back with possibly her most chilled out song yet. 'My Future' comes alongside a melancholy animated video starring Billie herself.