The 39 year-old's manager revealed the news, adding there are "at least seven suitors" that are being considered for future projects.
Chelsea Handler may be done with talk-show hosting.
The 39 year-old TV personality will walk away from E! as the host of 'Chelsea Lately' once her contract expires, according to The Hollywood Reporter.
Handler has taken the helm of her own show for the past eight years, debuting in 2007, and remains the only female late-night host on cable and network television.
Irving Azoff, the comedienne's manager, told the website, "Chelsea intends to leave when her contract expires. She hired me to figure out her life after E! We have at least seven suitors and many ideas."
He also revealed the future may involve being a radio personality or another hosting position for a nightly or weekly late-night show on a different media platform.
A spokesperson for E! also commented on her departure, stating, "Chelsea has nine months left on her contract and E! will not comment on the future of Chelsea Lately at this time."
Handler has not hidden her distain for E! and in a recent interview on Howard Stern's radio show she said the network is "a sad, sad place to live ... They don't know what they're doing. They have no ideas. It's a failure."
Earlier this month the 'This Means War' actress also hinted that she is ready to walk away from 'Chelsea Lately' when talking to USA TODAY, as she said, "I don't know if I want to be talking about Justin Bieber when I'm 40."
Handler also has other skills to fall back on, this announcement comes less than three weeks since she released her latest book 'Uganda Be Kidding Me', which peaked at No.1 on the New York Times bestseller list for over a week.
Her contract runs out this coming December (2014).
Chelsea Lately has been the host of her own talk-show since 2007
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