The pair last teamed up on 2018's 'One Kiss', and the superstar DJ took to TikTok this week to share a clip of the new song, 'Potion', coming together and the 'Levitating' hitmaker agreeing to add her vocals to the track.
After sharing clips of him playing the keyboard, guitar, bass and back to the guitar, Calvin FaceTimed Dua and she responds "definitely" when asked if she'll record her vocals on it.
A clip of the tune then plays with Dua singing: “Late night conversations, electric emotions / Sprinkled with a little bit of sex / and that’s a potion."
It's reported that Young Thug is also featured on the song.
Calvin is set to release 'Funk Wav Bounces Vol.2', the follow-up to 2017’s Funk Wav Bounces Vol 1, so it's likely 'Potion' will feature on that.
Teasing when fans can expect his upcoming sixth studio album, he tweeted last month: "Summer '22."
There's currently no official release date.
Mega-hit 'One Kiss' spent eight weeks at number one on the Official UK Chart upon its release in April 2018.
Meanwhile, Calvin is said to be engaged to Radio 1 DJ Vick Hope.
The 38-year-old music star is said to have proposed to the 32-year-old broadcaster at his home in sunny Spain after just five months of dating.
A source said this week: "Calvin proposed to Vick under his favourite tree on his farm Terra Masia in Ibiza.
"Vick said yes immediately, she is madly in love with Calvin and could not be any happier."
The Scottish star is next due to begin a summer residency at Ushuaïa Ibiza.
He will return to the famous super-club to play on Fridays from June 3 to September 2.
Former Bengal Lancer Harry Sullivan, aka From The Tiger's Mouth, has just released his first solo single - 'Morning News' under his new moniker.