Winona Ryder is set to make her big screen comeback as a femme fatale in new romantic comedy SEX AND DEATH 101. The HEATHERS star will play media sensation and urban legend DEATH NELL in the movie, which is currently being directed by Daniel Waters. In the film, Ryder will play one of Aussie actor Simon Baker's many conquests, who freak him out when they appear on a mysterious email that lists all of his past, present and future sexual partners. Baker's character is keen to avoid a romance with Ryder's Nell, despite the fact her name appears on the list, because she is famous for seducing men she declares guilty of sex crimes against women, and then putting them into fairy-tale-style comas. Australian pop sensation Sophie Monk and US TV star Julie Bowen appear among the other ladies on Baker's conquests list.