Ian Gray is a molecular biologist studying the evolution of the human eye. One day, a strange recurrence of the number 11 leads him to a photograph of a pair of eyes that could subsequently reveal the spiritual truth of the universe. The owner of the eyes is a girl named Sofi who, unlike Ian, believes that she has known him in a past life. Ian tends to avoid any non-scientific interpretation of his feelings but cannot hide the fact that he feels complete with her in his life. The pair fall quickly in love and decide to get married, but in a cruel twist of fate, she tragically and suddenly dies. Depressed and empty, Ian receives a call from his lab mate who reveals an impossible discovery; despite the fact that everyone is meant to have totally distinct eyes, she has found a person in India who shares the same irises as Sofi.
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In a city rife with crime and destruction, there's danger at every turn and suffering in every corner. The real authority of New York is The Shredder and his violent Foot Clan, whose power supersedes both police and politics. The only hope for restoring safety to the streets comes in the form of four mutant brothers, created in a laboratory many years ago and who have now found their way out of the sewers. A plucky newspaper reporter named April O'Neil is determined to land an exclusive story on the arrival of these martial art heroes alongside her cameraman Vernon Fenwick, but on being faced directly with these teenage mutant ninja turtles, she doesn't feel as brave as she first appears. However, if she wants to save the city from total obliteration, she and the masked mutants (Leonardo, Raphael, Michelangelo and Donatello) must team up and fight against Shredder and his formidable Clan.
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The film is expected to continue without Mendes' involvement.