The 'OMG' hitmaker and his protege have been confirmed to appear at the awards - which take place on February 13 in Los Angeles - to give a special performance alongside 'Karate Kid' actor Jayden Smith, son of rapper-turned-actor Will Smith.
The line up now means all five Album of the Year nominees - Eminem, Arcade Fire, Lady Gaga and Katy Perry are scheduled to perform at the show.
Eminem leads the night's awards with 10 nominations, and his producer, Alex Da Kid - who worked on his recent hit 'Love The Way You Lie' - warned that after two albums in as many years, he is liable to release new material at any time.
Alex told MTV: "We're constantly working and we never know what projects the things we're working on will land. I think he's in a great position where him and Dr. Dre can make music and whenever they feel like it, they can put it out.
"There's not a label telling them what to do, because they've been so successful, it's really up to him."