New instalments of the 1990s supernatural series will air on America's Showtime cable network early next year (17), and on Monday (25Apr16), bosses at the company unveiled the official cast list, which contains an impressive 217 people.
Among the notable names are Pearl Jam frontman Vedder and Nine Inch Nails rocker Reznor, whose bandmate Robin Finck is also set to appear. Other musicians include Sky Ferreira, Sharon Van Etten, Annie Hart, Erika Forster, and Heather D'Angelo.
Reznor previously composed the music for Twin Peaks creator David Lynch's 1997 film Lost Highway.
Other newcomers include actors Michael Cera, Jim Belushi, Jessica Szohr, Ernie Hudson, Tim Roth, Matthew Lillard, Monica Bellucci, Balthazar Getty, Francesca Eastwood, and UFC fighter Michael Bisping.
Naomi Watts, Jennifer Jason Leigh, Laura Dern, Amanda Seyfried and Ashley Judd are among the other new cast members who were previously announced.
They all join Sherilyn Fenn, Madchen Amick, Miguel Ferrer, Peggy Lipton, and Kyle MACLachlan, who are reprising their roles from the cult show.
Showtime executives have also confirmed filming has concluded on the 18-episode revival.