The 'Pass Out' rapper - who only released his debut single in February this year - is nominated for Best Newcomer, Best UK Act, Best Song and Best Video at the awards, which will be held in Liverpool, Northern England, on October 20.
When congratulated on his nominations, Tinie told BANG Showbiz: "Thank you, thank you very much. It's going to be hot."
N-Dubz, Dizzee Rascal, Professor Green and Plan B also scooped three nominations each for the ceremony - which awards musicians of any background who perform Music Of Black Origin and is celebrating its 15th year in 2010.
Speaking at the event, N-Dubz singer Tulisa - who previously scooped the prize with the group for Best Newcomer in 2007 - said: "I remember when we first started, looking at the MOBO Awards on the TV and thinking 'oh my god, how would it feel to win one of those?'
"When we finally did it was one of the most amazing feelings."
Her bandmate, rapper Fazer, added the award helped them get through a difficult period, as it shortly after the loss of their mentor Byron Contostavlos, who passed away just months before.
Other artists to receive nominations last night include Alexandra Burke, M.I.A and Leona Lewis who all in the Best UK act category, while Black Eyed Peas, Jason Derulo, Rihanna, Alicia Keys and Jay-Z were all nominated in the Best International Act section.
Fans can vote in all award categories by visiting www.mobo.com
Full list of MOBO nominations 2010
Best UK Act
Taio Cruz ft Ke$ha - 'Dirty Picture'
Tinie Tempah - 'Pass Out'
N-Dubz ft Mr Hudson - 'Playing With Fire'
Professor Green ft Ed Drewett - 'I Need You Tonight'
Best UK R&B / Soul
Best UK Hip Hop / Grime
Best International Act
Black Eyed Peas
Plan B - 'The Defamation of Strickland Banks'
JLS - 'JLS'
N-Dubz 'Against All Odds'
Chipmunk -'I Am Chipmunk'
Dizzee Rascal - 'Tongue in Cheek'
Mark Ronson & The Business INTL ft Q-Tip & MNDR - 'Bang, Bang, Bang'
Tinie Tempah ft Labrinth - 'Frisky'
Tinchy Stryder - 'You're Not Alone'
Alesha Dixon - 'Drummer Boy'
Dizzee Rascal - 'Dirtee Disco'
Best African Act
Hip Hop Pantsula (SA)
Banky W. (Nig)
Concha Buika (Equatorial Guinea)
Mulatu Astatke (Ethiopia)
Wanlov the Kubolor (Ghana)
AngÃ©lique Kidjo (Benin)
Yuri Da Cunha (Angola)
Waldemar Bastos (Zimbabwe)
Staff Benda Bilili (Congo-Kinshasa)
BLK JKS (South Africa)
Best Gospel Act
Best Jazz Act
Robert Glasper - 'Double Booked'
Brad Mehldau - 'Highway Rider'
Empirical - 'Out 'n' In'
Phronesis - 'Alive'
John McLaughlin - 'To the One'