The British rappers will be hoping to show off their driving skills when they command luxury supercars in the annual race, which will begin in Miami, Florida, on June 2 and culminate in the party island of Ibiza.
'Miami 2 Ibiza' hitmaker Tinie will have the chance to turn his lyrics into a reality when he joins the 10-day race.
Fellow rapper Dizzee is expected to commandeer the world's fastest supercar, the Bugatti Veyron, which is worth £1 million, for his second Gumball 3000 Rally.
The racers will begin their jaunt in Miami, travel to New York and Atlanta, and then hop on a plane to Edinburgh, Scotland, for the European leg of the rally. The luxurious cars are expected to stop traffic in London's famous Regent Street, which will be shut down to accommodate the 120 vehicles flown in for the rally.
The stars and their cars will then drive to Paris, France, and Barcelona in Spain before wrapping the race with a massive party in Ibiza.