The film begins with Lisa (Rachel McAdams), a driven professional, on her way to board the eponymous flight from Dallas to Miami. When the flight is delayed, she meets Jackson (Cillian Murphy), who, after some clumsy flirting, gains her trust. By apparent coincidence, they end up seated together when the flight finally takes off. Unfortunately, Jackson turns out to be part of a conspiracy to kill a Homeland Security bigwig and Lisa is a key to their plans. Jackson tells her that if she doesn't help, a man is waiting outside her father's house, ready to kill him.
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There's already an Oscars buzz surrounding this movie.