Director Steven Soderbergh's star-studded disaster movie Contagion has topped the U.S. box office.
The film, about a deadly virus, opened with $23.1 million (£14.4 million) over the weekend (09-11Sep11).
Summer sleeper hit The Help dropped to second after spending three weeks at the top.
Mixed martial arts movie Warrior opened with $5.6 million (£3.5 million). The Debt and Colombiana round out the new top five.