The late actor will be honoured for his career achievements on 2 December (13) at Cipriani Wall Street in New York.
Buscemi says, "James Gandolfini was a friend, an inspiration, and an extraordinary talent whose presence is missed by all of us who knew and loved him. It is an honour to present this tribute at the Gotham Awards recognising his impact."
Other honourees at the 23rd annual New York awards show include Forest Whitaker, director Richard Linklater and media executive Katherine Oliver.
Gandolfini passed away after suffering a heart attack while vacationing in Italy in June (13).