As the physicist ponders mankind's greatest achievements, Stiller's dim-witted model character Derek Zoolander asks, "If God exists, then why did he make ugly people?"

He then struggles with the title of the new movie, Zoolander II, insisting he's not Italian - and therefore doesn't understand Roman numerals.

Hawking finally gives up trying to explain the title to Zoolander, stating, "Jesus, you are so freaking stupid, it's insane!"'