The plot is loosely framed around the kilt-wearing master chemist Elmo McElroy (Samuel L. Jackson) who has developed a new illegal drug that produces a high that is 51 times better than cocaine, acid, or ecstasy. When McElroy attempts to sell the drug's formula to a mobster named The Lizard (Meat Loaf), the deal goes bad and McElroy flees to Liverpool with only his golf clubs. While there, he meets up with Yankee-hating thug Felix DeSouza (Robert Carlyle) assigned to help McElroy score $20 million for the drugs from a local gangster (Ricky Tomlinson). Unfortunately, this deal also fails. DeSouza and McElroy must now find new buyers while staying clear of other rogue groups who want the formula, and an assassin (Emily Mortimer) hired by The Lizard to return McElroy to the states.
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