In the opening scene, Tum (Pen-Ek Ratanaruang) is in the midst of being laid off as a secretary. She gets home and is so despondent she dreams of suicide. The next morning, a package mysteriously arrives at her apartment (#6): It's a box full of cash. Before she can figure out what to do with it, the two thugs who live in apartment 9 come looking for it. You see, that 6 on Tum's door got flipped over... hence the title (literally translated "a funny thing about 6 and 9"). The thugs end up dead, and Tum is faced with disposing of the bodies, while she tries to figure out a way to get out of the country with the cash.
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The film is expected to continue without Mendes' involvement.