The 'This Is the End' star lashed out at the 19-year-old singer on Twitter after he was charged with drink driving, resisting arrest and drag racing in Miami, Florida on Thursday morning (23.01.14).
The 31-year-old comedian and actor tweeted: ''All jokes aside, Justin Bieber is a piece of s**t.''
The post was shared by more than 70,000 other users within four hours.
Seth's blast will come as a surprise to some fans as he was spotted bonding with the Canadian singer at the MTV Video Music Awards at the Nokia Theatre in Los Angeles in 2011.
'Girls' star and creator Lena Dunham also tweeted: ''The only crazy part of Justin Bieber arrest is that he was 'popping anti-depressants all day.' Anti-depressants take like 3 months to work.''
However, the 'Baby' hitmaker received some much needed support from Lady GaGa, who urged her fans not to judge him at this tough time.
In a post on her website LittleMonsters.com, the 27-year-old 'Applause' singer wrote: ''Hey monsters. I know everyone today is taking about Justin's arrest and all sorts of words and judgements are happening on the Internet.''
She also encouraged her followers to support Justin and his fans, known as Beliebers.
She wrote: ''Everyone is entitled to their own opinion, and to stand up for themselves, but I think we should be supportive of Beliebers.
''They deserve, just like any other fan, to feel strong for each other and Justin so they can continue to share the bond they have through music. We may not understand everything celebrities do because there's only so much we see, but Justin and Beliebers were 'born this way' too. Let's spread love and compassion to Beliebers today. That is what we are all about.''
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