The pair have remade the raunchy clip - which sees Kanye riding a motorbike while straddled by his topless fiancee, Kim Kardashian - shot-for-shot and re-titled it 'Bound 3'.
In the new version, Seth plays the role of Kim, and dry humps James - wearing a tie-dye T-shirt - as they ride in front of a desert backdrop.
Introducing the clip, James wrote on instagram: ''#bound3 #sethrogen #love - A LITTLE VIDEO SeTH AND I mADE IN OUR DOWN TIME. (sic)''
Next to another still, which shows them appearing to kiss passionately, he added: ''I LOvE SETh (sic)''
James and Seth made the spoof clip during a break from filming their latest movie together, 'The Interview'.
Kanye premiered the video to 'Bound 2' last week, and when asked about the decision to include so many raunchy images of his partner - who gave birth to the couple's first child, North West, in June before embarking on a crash weight-loss diet to regain her figure - said he felt she ''deserved'' a starring role.
He said: ''It was just awesome. I think that Kim is awesome and she just deserved an awesome moment like that.''
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