Miller's mother Adele was diagnosed with the disease in 2006, at the age of 55, and the actress admits the situation has been very hard on her.
In an interview with U.S. breakfast show Today, she says, "It can be brutal. I'm sort of at that point in my life where a lot of my girlfriends are becoming best friends with their mother and, you know, on Sunday I fed my mom dinner."
The Knocked Up star and Miller are hoping to spark dialogue by organising "fun" events to get young people "excited" about participating and helping.
In April (13), the couple held a fundraiser through their charity Hilarity for Clarity, and recruited Kevin Hart, the Backstreet Boys and actor Samuel L. Jackson to help spread the message.
Rogen says, "It's such a bummer of a disease, you almost have to have the most fun charity event imaginable to counteract that weight in some way and make people excited about participating. But I think were making it a part of a conversation its not normally a part of."