Cruise - who claims to have helped people fight drug addictions through his controversial Scientology religion - sparked a war of words when he criticised Shields in May (05) for using anti-depressant Paxil, following the birth of her daughter ROWAN.
The Island actress brands the WAR OF THE WORLDS star as "ignorant" and insists women should have the right to choose how they treat their body.
She says, "I think people have their own right to choose whether or not they want to stop taking a drug.
"I can go into a very lengthy conversation with anyone about a woman's right to choose and things like that, but I don't believe in forcing my opinion on people.
"I do believe that, in particular, children are over medicated.
"But I've also known people who've taken anti-depressants for a couple of months, and it saves them from what could really be a drastic situation.
"Ruling out something that could legitimately help people seems ignorant."