The comedienne will front The Maya Rudolph Show, a one-off special that executives at America's NBC network have described as a revival of the classic variety show format.
Rudolph has recruited some of her former Snl co-stars to appear on the programme, including Andy Samberg, Fred Armisen and Chris Parnell, as well as actors Sean Hayes, Kristen Bell and The Office's Craig Robinson.
Janelle Monae is set to serve as the musical guest, with soul legend Raphael Saadiq serving as bandleader.
Rudolph last starred in the short-lived Nbc sitcom Up All Night with Christina Applegate and Will Arnett, until it was cancelled after two seasons in 2012.
The Maya Rudolph Show will air in America on 19 May (14).