The Hollywood beauty claimed the first three prizes of Wednesday's (08Jan14) ceremony as she picked up the title for Favorite Movie Actress and was handed trophies for Favorite Comedic and Dramatic Movie Actress, too.
Her space disaster film, Gravity, was also named Favorite Dramatic Movie and her onscreen work with George Clooney landed her the Favorite Movie Duo award.
Timberlake was a triple threat at the Los Angeles ceremony, claiming Favorite Male Artist, R&B Artist and Favorite Album for The 20/20 Experience.
Robert Downey, Jr. was another big winner - he walked away as the Favorite Action Movie Star, while his superhero blockbuster Iron Man 3 was named Favorite Movie and Favorite Action Movie.
Newlywed Kaley Cuoco was given another couple of reasons to celebrate - she was handed the Favorite Comedic TV Actress honour for The Big Bang Theory, while the sitcom was also the winner of the Favorite Network TV Comedy category.
As she accepted her acting accolade, Cuoco, who wed tennis player Ryan Sweeting on New Year's Eve (31Dec13), gave a special shout out to her new husband, saying, "This is the second best thing that happened to me all year; the first was marrying you baby! I love you."
Meanwhile, Jennifer Hudson fought back tears as she was hailed the Favorite Humanitarian for her work with the Julian D. King Gift Foundation, the children's organisation she founded in 2008 to help underprivileged kids following the murder of her seven-year-old nephew.
She stepped onstage with her sister Julia to accept the award and paid tribute to her late mother and brother, who were also killed in the family tragedy, telling the crowd: "We wanna dedicate this to our mother, who taught us... that without family, you have nothing, and our brother, who was the most giving."
Awards co-hosts Kat Dennings and Beth Behrs kicked off the show with a skit straight from the diner of their hit sitcom 2 Broke Girls, featuring guest appearances by The Vampire Diaries' Ian Somerhalder, The Crazy Ones' Sarah Michelle Gellar, Christina Aguilera, Ian Ziering, The Big Bang Theory co-stars Mayim Bialik and Melissa Rauch, and talk show host Arsenio Hall. Cuoco also made a cameo in the opening sketch, handing over the honour of presenting the prizegiving after joking that she was going to be busy on the night of the event.
Musical performances came from the likes of Brad Paisley and OneRepublic, and presenters included LL Cool J, Zac Efron, Heidi Klum, Jessica Alba and Malin Akerman.
The full list of winners is as follows:
Favorite Movie - Iron Man 3
Favorite Movie Actor - Johnny Depp
Favorite Movie Actress - Sandra Bullock
Favorite Movie Duo - Sandra Bullock and George Clooney (Gravity)
Favorite Action Movie - Iron Man 3
Favorite Action Movie Star - Robert Downey, Jr.
Favorite Comedic Movie - The Heat
Favorite Comedic Movie Actor - Adam Sandler
Favorite Comedic Movie Actress - Sandra Bullock
Favorite Dramatic Movie - Gravity
Favorite Dramatic Movie Actor - Leonardo DiCaprio
Favorite Dramatic Movie Actress - Sandra Bullock
Favorite Family Movie - Despicable Me 2
Favorite Horror Movie - Carrie
Favorite Thriller Movie - Now You See Me
Favorite Network TV Comedy - The Big Bang Theory
Favorite Comedic TV Actor - Chris Colfer (Glee)
Favorite Comedic TV Actress - Kaley Cuoco (The Big Bang Theory)
Favorite Network TV Drama - The Good Wife
Favorite Dramatic TV Actor - Josh Charles (The Good Wife)
Favorite Dramatic TV Actress - Stana Katic (Castle)
Favorite Actor in a New TV Series - Joseph Morgan (The Vampire Diaries)
Favorite Actress in a New TV Series - Sarah Michelle Gellar (The Crazy Ones)
Favorite TV Crime Drama - Castle
Favorite Competition TV Show - The Voice
Favorite Cable TV Comedy - Psych
Favorite Cable TV Drama - The Walking Dead
Favorite Premium Cable TV Show - Homeland
Favorite Cable TV Actress - Lucy Hale (Pretty Little Liars)
Favorite TV Anti-Hero - Andrew Lincoln (The Walking Dead)
Favorite TV Bromance - Jared Padalecki, Jensen Ackles and Misha Collins (Supernatural)
Favorite TV Gal Pals - Lea Michele and Naya Rivera (Glee)
Favorite On-screen Chemistry - Ian Somerhalder and Nina Dobrev (The Vampire Diaries)
Favorite Sci-Fi/Fantasy TV Show - Beauty and the Beast
Favorite Sci-Fi/Fantasy TV Actor - Ian Somerhalder
Favorite Sci-Fi/Fantasy TV Actress - Kristin Kreuk (Beauty and the Beast)
Favorite TV Movie/Miniseries - American Horror Story
Favorite Daytime TV Host - Ellen DeGeneres (The Ellen DeGeneres Show)
Favorite New Talk Show Host - Queen Latifah (The Queen Latifah Show)
Favorite Late Night Talk Show Host - Stephen Colbert (The Colbert Report)
Favorite Streaming Series - Orange Is the New Black
Favorite Series We Miss Most - Breaking Bad
Favorite New TV Comedy - Super Fun Night
Favorite New TV Drama - Reign
Favorite Male Artist - Justin Timberlake
Favorite Female Artist - Demi Lovato
Favorite Breakout Artist - Ariana Grande
Favorite Pop Artist - Britney Spears
Favorite Country Artist - Taylor Swift
Favorite Country Music Icon - Tim MCGraw
Favorite Hip Hop Artist - MACklemore & Ryan Lewis
Favorite R&B Artist - Justin Timberlake
Favorite Band - One Direction
Favorite Alternative Band - Fall Out Boy
Favorite Song - Roar by Katy Perry
Favorite Album - Justin Timberlake (The 20/20 Experience)
Favorite Music Video - Roar by Katy Perry
Favorite Music Fan Following - Demi Lovato's Lovatics
Favourite Humanitarian - Jennifer Hudson.