The actors are both nominated for the Best Drama Actor award, Ryan for his role in 'The Ides of March' and George for 'The Descendants'.
Elsewhere Angelina Jolie's directorial debut, 'In The Land of Blood and Honey', scored a nomination in the Best Foreign Language category, leaving the actress ecstatic.
She told The Hollywood Reporter: "I was on my way and turned on my phone, and saw the subject line on an email. I thought, this can't be. I never expected this.
"Just to be able to make a film you care about and then get a distributor makes you happy."
The 69th Annual Golden Globes are set to be held in Beverly Hills, California, on January 15, 2012, with Ricky Gervais set to host the ceremony for the third time.