Editors at the publication have determined Pattinson and Stewart are the hottest duo after raking in $625 million (£391 million) for the Twilight franchise.
Channing Tatum and his The Vow co-star Rachel MCAdams, who brought in $125 million (£78 million), come in second.
The top two leading men landed on the list twice - Pattinson and Reese Witherspoon won over viewers in Water for Elephants, while People magazine's current Sexiest Man Alive movie romance with Amanda Seyfried in Dear John put them sixth.
Also making the top 10 were Miley Cyrus and Liam Hemsworth, who met and fell in love while filming The Last Song, and Zac Efron and Taylor Schilling, whose steamy love scenes in The Lucky One earned them a spot at number nine.
Forbes editors compiled the list using the top money-making romantic movies over the past three years.