The Hollywood legends first teamed up in 1973 on crime drama Mean Streets and went on to make a number of films together, including Mafia-themed classics Goodfellas and Casino.
De Niro has now confirmed the pair will reteam for a ninth project, and return to their beloved gangster genre.
He says, "I have another gangster film I'm gonna do with Scorsese and it's a very interesting one. We're preparing it. We have a script and Marty has another film he's doing before so it won't be for a while."