The People's Choice awards have been given out during a pre-recorded show due to the ongoing effects of the Hollywood writers' strike.
With Sunday's Golden Globe awards ceremony already cancelled due to the industrial action, the People's Choice prizes were handed out during a magazine-style show hosted by Queen Latifah.
The majority of the members of the Screen Actors' Guild (SAG) have expressed sympathy with the striking Writers Guild of America (WGA) and are not crossing picket lines, leading to the cancellation of the Golden Globes ceremony and the potential jeopardising of the 80th Academy Awards.
Pirates Of The Caribbean and Grey's Anatomy were the big winners at the 34th annual show with four awards for Disney's swashbuckling caper and three for the CBS medical drama.
But because of the strike - which concerns the payment of royalties to writers when their work is redistributed on DVD, mobile phones or the internet - the trophies were presented to the stars in person, with Grey's Anatomy leading man Patrick Dempsey given his award while at the Daytona International Speedway in Florida.
The show would never have been cancelled however, Queen Latifah explained.
"The thing about the People's Choice awards that's different from everybody else is it's the people's choice," she said.
"You can't disrespect the people who keep us working, and that's the people. Ten million people logged on and voted for everyone, so out of respect for them, we have to present the awards."
Justin Timberlake also won three awards while The Bourne Ultimatum won prizes for best action movie and best male action star for Matt Damon.
The complete list of winners is below:
Favourite leading lady: Drew Barrymore
Favourite leading man: Joaquin Phoenix
Favourite action movie: The Bourne Ultimatum
Favourite male movie star: Johnny Depp
Favourite female movie star: Reese Witherspoon
Favourite male action star: Matt Damon, The Bourne Ultimatum
Favourite female action star: Keira Knightley
Favourite onscreen match-up: George Clooney and Brad Pitt, Ocean's Thirteen
Favourite movie drama: Harry Potter and the Order of the Phoenix
Favourite movie comedy: Knocked Up
Favourite independent movie: Becoming Jane
Favourite family movie: Shrek the Third
Favourite threequell: Pirates of the Caribbean: At World's End
Favourite movie: Pirates of the Caribbean: At World's End
Favourite funny male star: Robin Williams
Favourite funny female: Ellen DeGeneres
Favourite TV comedy: Two and a Half Men
Favourite male TV star: Patrick Dempsey, Grey's Anatomy
Favourite female TV star: Katherine Heigl, Grey's Anatomy
Favourite scene-stealing star: Chandra Wilson, Grey's Anatomy
Favourite game show: Deal or No Deal
Favourite animated TV comedy: The Simpsons
Favourite sci-fi show: Stargate Atlantis
Favourite competitive reality show: Dancing With the Stars
Favourite new TV comedy: Samantha Who?
Favourite new TV drama: Moonlight
Favourite TV drama: House
Favourite R 'n' B song: Shut Up and Drive - Rihanna
Favourite group: Rascal Flatts
Favourite male singer: Justin Timberlake
Favourite female Singer: Gwen Stefani
Favourite reunion tour: The Police
Favourite pop song: What Goes Around Comes Around - Justin Timberlake
Favourite country song: Stand - Rascal Flatts
Favourite rock song: Home - Daughtry
Favourite hip-hop song: Give it to Me - Timbaland feat. Justin Timberlake and Nelly Furtado
Favourite song from a soundtrack: You Can't Stop the Beat from Hairspray