The reformed group - who made their live return last year after an eight-year absence - will headline the prestigious venue on March 31, the day after rapper Example opens the event.
Florence and the Machine will close the five-day series of gigs on April 3.
He said: "Every year my team and I work really hard to make these concerts for Teenage Cancer Trust something special.
"This year is no exception and the line-up of artists donating their time and talent is incredible. I hope there is something for everyone. I'm proud to be a patron of Teenage Cancer Trust. I've been involved for nearly 20 years and this is the twelfth year we've staged these shows.
"I might be a rock star but I'm also a dad. I know teenagers aren't children and they are certainly not quite adults either.
"They are a group all on their own and they need to be recognised as that."
Across the past 11 years, the gigs have raised over £14 million for the Teenage Cancer Trust, with all funds going towards building specialist cancer units in NHS hospitals.