The Black Sabbath frontman will receive the Stevie Ray Vaughan Award for his dedication and support of the MusiCares MAP Fund, and he will also perform at the gala with guitarist Slash.
A spokesman for the event says, "He is being recognised for his commitment to helping other addicts with the addiction recovery process."
Osbourne adds, "I know firsthand about the ravages of addiction and I also know that the MusiCares MAP Fund is a vital safety net for people in the music industry who need help with substance abuse. This organisation literally saves lives."
Meanwhile, top DJ Mix Master Mike will celebrate the memory of Goldstein, aka Dj Am, who lost his battle with drug abuse in 2009.