The singer was "appalled" by a story, published in The Mirror on Saturday (10Aug13), which took aim his midwife mother, Johannah, and her fiance Daniel Deakin.
Tomlinson has now launched a scathing rant against the tabloid, insisting the group will never work with the paper again.
In a series of posts on his Twitter.com page, he writes, "I am appalled by what The Mirror has done to my family. It's disgusting and immoral. F**k you The Mirror... As long as I am in One Direction we won't be working with The Mirror."
The star previously criticised tabloid bosses back in March (13) for running an interview with his estranged father.