The news that Do No Harm has been cancelled will come as quite a shock, especially considering the show only lasted 2 episodes. 

It was, unfortunately, the lowest-rated in-season broadcast scripted series premiere in the history of the Big Four networks. And this week it fell another 22 percent among the much-coveted 18-49 year old viewers, who count for the most with NBC ad sales executives. Failure in that respect effectively sealed its doom. The 10pm Thursday space has been a bone of contention for the network, who can't seem to find a consistent show to fill the troublesome slot. They now have a decision to make; they could put Rock Center back in the slot or try another new drama, Hannibal, which is ready to go on the air. That or try and commission a brand new drama to pull in those valuable viewers. In the meantime they'll be running Law & Order: SVU reruns. 

The news marks a dark week for NBC, who learnt that 50% of Up All Night's core - Christina Applegate - was leaving the show. "It's been a great experience working on 'Up All Night' but the show has taken a different creative direction and I decided it was best for me to move on to other endeavors," Applegate said Friday in a statement.