The 56-year-old actress has allegedly cited irreconcilable differences as the reason behind their split in the legal documents filed by her attorney Laura Wasser.
The 'Working Girl' star is reportedly asking for child support and sole physical and joint legal custody of their 17-year-old daughter Stella, as well as spousal support, according to gossip website TMZ.com.
It is believed the split is amicable, but their divorce could turn complicated when it comes to dividing up property as they own a number of homes in the US and Spain.
The Hollywood couple first got together after meeting on the set of the 1995 film 'Two Much', which led to Antonio's divorce from Ana Leza.
The pair got married in a low key ceremony in London, England, in 1996, just one month after Antonio, 53, and Ana's divorce was finalised.
Rumours began to swirl earlier this year that the duo's relationship had hit the rocks, but they both denied there were any issues.
Meanwhile, this will be Melanie's fourth divorce following her failed relationships with Don Johnson, whom she married twice, and Steve Bauer.
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