The 56-year-old singer thinks the 'Bound 2' hitmaker can be ''inappropriate'' with his opinions but she is astonished by some of his ideas.
She said: ''He can't help himself. Like, he doesn't have the same filters other people have.
''He has to blurt things out, he's always saying inappropriate stuff. But he also has brilliant ideas, if you can get him to pay attention long enough, working with him in the studio.''
And the 'Hung Up' hitmaker admits working on her new album, 'Rebel Heart', with Kanye and some of her other collaborators drove her ''bonkers'' because of their lack of focus and easily-distracted ways.
She said: ''He would drive me bonkers, because he's got so many things going on in his life. And this seemed to be the theme of my record, working with people who can't get off their phone, can't stop tweeting, can't focus and finish a song. It drove me crazy. But when they did pay attention, it was brilliant. I was, like, running around with a butterfly net.''
Last month, Kanye tried to interrupt Beck as he accepted the Album of the Year prize at the Grammy awards to signal that, like at the 2009 MTV Video Music Awards - when he interrupted Taylor Swift's acceptance speech - he felt Beyonce should have picked up the accolade, and Madonna thinks he picked the wrong time and place to try and make a statement.
She told the new issue of Rolling Stone magazine: ''Don't go to awards shows looking for justice.
''That's like trying to find a needle in a haystack. Just go and have fun. I never got too engaged with who wins awards or not, because I don't honestly think it's that important.
''So that part of him I can't relate to. Like, what's the point of fighting for somebody to...like, 'This person should have got it?'...I think sometimes he takes things too seriously.''
While Madonna doesn't always agree with Kanye, she thinks he is good for the music industry.
She said: ''I feel like the music business needs him, because everyone's become so politically correct, so safe.
''I don't always agree with the things he says or does - I don't always like his music, even. But he's a beautiful mess. I love him.''
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