Wayne - the founder and co-head of Young Money Entertainment, the label Drake is signed to - has called on the musician and the 'Yeah 3x' singer to stop arguing because it is bad for business.
Drake and Chris have been at war due to their individual romantic relationships with Rihanna and their argument spilled into violence last week when a huge brawl erupted in a New York nightclub between them and their entourages, which left Chris with a cut to his lip, and various bystanders injured.
Sources say several people from Young Money including Wayne, Birdman and co-founder Mack Maine, have called Drake to tell him to make up with Chris.
They are keen for him to end the beef because many of the label's acts have appeared on tracks with Chris and he is behind a number of their hit records and while the company say will stand by Drake no matter what, one source told TMZ.com: ''Making money matters most.''
Drake is said to be unwilling to make amends with Chris until he says he wasn't responsible for the fight at the W.i.P club last week.
Despite the altercation, Drake's friend Meek Mill has insisted there are no huge problems between the two.
He said: ''I talked to Chris immediately after that, on the phone. There's nothing there. Chris Brown be in clubs. He be around situations like this.
''Things get out of hand. That don't mean it's out of hand with me and him or whoever, not even him and Drake.''