The Underworld filmmaker was set to breathe new life into the popular series, which grossed over $1.3 billion at the box office worldwide with a trilogy of films starring Brendan Fraser between 1999 and 2008.
However, Wiseman has now exited the upcoming fourth installment over scheduling conflicts, reports The Wrap.
After coming onboard the project, Kate Beckinsale's husband revealed producers behind the reboot wanted to make a much darker movie than its predecessors.
He told Deadline.com, "When I first heard Universal was relaunching this, that is the image that popped into my head, the period tale, the old monster, but when (the producers) pitched it, there was a great new take and approach, and a very different mummy as well. It's a darker twist on the material, a scarier version."