The Dutch supermodel signed an exclusive deal with the fashion house to front its campaigns for Calvin Klein Jeans, Calvin Klein Collection and ck Calvin Klein.
She said: "I have a long history with the Calvin Klein brand, and so it was wonderful to work with the house again this year. It's like being part of a family."
He said: "I conceived my autumn 2010 collection with a self-aware and assured woman in mind. For me, Lara was the perfect choice for the new campaign because she is a woman who epitomises confidence and sensuality."
Lara - whose UK size eight figure is deemed 'curvy' by catwalk standards - has taken the fashion world by storm and is currently the face of Prada's Infusion d'Iris scent, Louis Vuitton, Jaeger and Eres.
She has previously said she thinks her curvy figure has helped her become a success.
She said: "I'm different because I am fat. It would be nice if I wasn't the only person with t*ts and an a**e.
"If I could have the discipline to be super-skinny I would be. I think of dieting, then I eat pizza. I'm a woman, and every woman wants to be thinner - unfortunately."