Harris recently told the Bbc he spurned Gaga's attempts to work with him at the beginning of her career because he wasn't a fan.
He explained, "You have got to pick people whose songs or voice you like and at that stage, it was before she was really big, and they sent me some songs and I didn't really like the songs."
Lady Gaga is far from amused by Harris' frank confession and she took to Twitter.com to blast his claims, stating, "(I) never even emailed you @calvinharris I guess it's hard to believe I write + produce my music. cuz (because) I'm a woman I don't know about Edm (electronic dance music) right?"
Gaga appears to be making quite a few enemies in the music world these days - earlier this month (Oct12) she fired off at South Affrican hip-hop collective Die Antwoord after they poked fun at her in a video.