The 28-year-old reality star impressed TV bosses with her bubbly personality and witty comebacks during her screen test, and producers including Simon Cowell want her to present the Fox reality show in a bid to attract younger viewers.
A source told TMZ.com: ''There's at least an 85 per cent chance she'll get the job.''
The 'Keeping Up with the Kardashians' star is said to be the first choice over other contenders including Kelly Osbourne, Mario Lopez and Stacy Keibler in the fight to replace Steve Jones as the host of the show's second season.
The feisty socialite recently expressed her interest in the presenting job, saying: ''I'm a big fan of 'The X Factor'. I've always wanted to do hosting or talk show hosting, so it's definitely something that I would love to do and would be honoured to do.
''To be on such a huge show like that with those judges, I would have so much fun doing that. I love Simon (Cowell). I think he's amazing.''
Khloe has a free schedule after suspending filming of her E! reality show 'Khloe And Lamar' to let her basketball player husband Lamar Odom get his sports career back on track.