According to gossip website TMZ, the 29-year-old reality TV - who wed the basketball player in September 2009 - will allegedly cite ''irreconcilable differences'' in her legal documents to end her marriage to the 34-year-old hunk.
The couple are said to have signed an ''ironclad'' prenuptial agreement which will help to divide all their significant assets.
Khloe and Lamar attended a Jay-Z concert separately on Monday (09.12.13) at the Staples Centre in Los Angeles, California, and they reportedly did not speak to each other.
The brunette beauty has been spotted without her wedding ring on for more than two weeks following allegations which emerged earlier this year that Lamar cheated on her with multiple other women and has also battled a cocaine addiction.
Lamar recently defended himself after a freestyle rap video of him slurring his words in a song which referenced being unfaithful and smoking drugs was posted online.
He told friends there were no drugs involved and he was determined to resurrect his basketball career.
Earlier this week, Us Weekly claimed the 'Keeping Up With The Kardashians' star was set to file for divorce ''very soon''.
This Doctor won't be saying 'goodbye' in the same way as those who have left the series in recent years.