The Don't Kill My Vibe hitmaker, who went into the prizegiving with 14 nods, walked out with five awards, including Lyricist of the Year, Mvp of the Year, and Sweet 16, which honours the best featured 16-bar verse on a single track.
Lamar also took home Album of the Year for good kid, m.A.A.d city, as well as Best Collabo for his contribution to A$AP Rocky's hit song, Problems.
Drake scooped four awards - Best Hip-Hop Video, Track of the Year, People's Champ Award and Best Club Banger, for his featured rhymes on French Montana's Pop That.
Veteran Jay Z added two honours to his collection by winning Best Live Performer and Hustler of the Year.
The ceremony, which aired in the U.S. on Tuesday (15Oct13), but was filmed in Atlanta, Georgia, last month (Sep13), was hosted by Snoop Lion and included performances by Montana, Rick Ross, 2 Chainz, Bone Thugs-n-Harmony and Lamar, who proved he was worthy of the accolades with an impressive four-minute freestyle rap.