The supermodel was devastated when she was not selected to be one of a host of models to appear in the singer's 1990 'Freedom' promo - which featured Naomi Campbell, Linda Evangelista and Cindy Crawford - and to make up for it he has asked her to appear in his latest project.
However, rather than posing alongside a group of other models in George's video - believed to be for is comeback song 'White Light' - she will work with a zebra.
A source told the Daily Mirror newspaper: ''Kate is a huge fan of George's and always has been.
''She's been to heaps of his concerts and she was really good friends with his ex-boyfriend Kenny Goss, too.
''When she said last year that she was upset she didn't get to star in the 'Freedom' video, it got everybody involved in George's new track thinking.
''She was offered a cameo role in the new video as long as she could make it along to the studio for the shoot.
''She was delighted to be offered, and if everything goes to plan, she'll appear in it.''
'White Light' was written about George's battle with pneumonia last year, which saw him hospitalised and close to death. In one scene of the proposed video he will be seen falling to the ground.
Kate and George are also set to appear alongside each other at the closing ceremony of the London 2012 Olympics.
'Fast Love' singer George will perform at the closing concert on August 12, while Kate will represent British fashion posing alongside Rosie Huntington-Whiteley and Naomi in creations by Alexander McQueen and Vivienne Westwood.