Annie Parker is a fun-loving young woman struggling with the difficulties of motherhood, a husband who's slowly losing interest and, more importantly, breast cancer. She is unsurprised that she has become afflicted with the disease following her mother and older sister's suffering, but she suddenly finds herself overcome with the determination to find out why. Meanwhile, a young research geneticist named Mary-Claire King is looking into a breakthrough theory that suggests that some women are genetically pre-disposed to have breast cancer due to a particular gene. Unfortunately for her, there are few scientists who believe her theory. In order to prove her theory, she must conduct a research project looking into cancer sufferers' and their relatives' medical history - and that's where Annie Parker is eager to help.

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